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EXTENDED ANTICOAGULANT THERAPYIN PATIENTS, WHO SURVIVED PULMONARY EMBOLISM

https://doi.org/10.21518/2307-1109-2018-2-36-45

Abstract

The review article discusses the options to extend anticoagulant therapy after completing the main anticoagulant therapy course in patients, who survived pulmonary embolism. It presents the results of randomized RE-MEDY and RE-SONATE studies of dabigatran, EINSTEIN-Extension study of rivaroxaban and AMPLIFY-Extension study of apixaban, which evaluated the feasibility, efficacy and safety of extended anticoagulant therapy with direct acting oral anticoagulants compared with placebo or warfarin. The article also provides the results of ASPIRE and WARFASA studies, which evaluated the possibility of using low-dose aspirin vs. Placebo for the extended treatment. The authors reviewed in details the results of einstein choice study, in which they compared the extended therapy with two doses of rivaroxaban (10 or 20 mg once a day) versus low (100 mg/day) doses of aspirin and against each other. The data obtained indicate that both doses of rivaroxaban significantly exceed aspirin in efficacy and reduce the risk of recurrent venous thrombosis by 74 and 66 %, respectively, without significantly increasing the risk of bleeding.

About the Authors

Natalia M. Vorobieva
Federal State Budgetary Educational Institution of Higher Education «Pirogov Russian National Research Medical University», of the Ministry of Health of Russia, a separate structural subdivision – Russian Gerontological Research and Clinical Center
Russian Federation

Vorobieva Natalia Mikhailovna – Dr. of sci. (Med.), senior Researcher of the Cardiovascular Aging Research Laboratory

tel.: +7 (499) 187–12–54

16 Pervaya Leonova str., 129226, Moscow


Elizaveta P. Panchenko
Federal State Budgetary Institution «National Medical Research Center of Cardiology» of the Ministry of Health of the Russian Federation
Russian Federation

Panchenko Elizaveta Pavlovna – Dr. of sci. (Med), Professor, Head of Department of Clinical Problems in Atherothrombosis

tel.: +7 (495) 150–44–19

15А Tretia Cherepkovskaya str., Moscow, 121552


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Review

For citations:


Vorobieva N.M., Panchenko E.P. EXTENDED ANTICOAGULANT THERAPYIN PATIENTS, WHO SURVIVED PULMONARY EMBOLISM. Aterotromboz = Atherothrombosis. 2018;(2):36-45. (In Russ.) https://doi.org/10.21518/2307-1109-2018-2-36-45

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ISSN 2307-1109 (Print)
ISSN 2658-5952 (Online)