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ВОЗМОЖНОСТИ ДАБИГАТРАНА ЭТЕКСИЛАТА В ЛЕЧЕНИИ ВЕНОЗНЫХ ТРОМБОЭМБОЛИЧЕСКИХ ОСЛОЖНЕНИЙ

https://doi.org/10.21518/2307-1109-2015-2-17-31

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Аннотация

В данной статье обсуждаются возможности использования нового перорального антикоагулянта — дабигатрана этексилата — для лечения венозных тромбо-эмболических осложнений (ВТЭО). Представлены результаты 4 рандомизированных клинических исследований — RE-COVER, RE-COVER II, RE-MEDY и RE-SONATE. В RE-COVER и RE-COVER II сравнили эффективность и безопасность дабигатрана и варфарина у больных с острым эпизодом ВТЭО, а в REMEDY и RE-SONATE оценили целесообразность продления терапии дабигатра-ном у больных ВТЭО, завершивших основной 3—6-месячный курс лечения антикоагулянтами. При этом в RE-MEDY дабигатран сравнили с варфарином, а в RE-SONATE — с плацебо. По итогам RE-COVER, RE-COVER II и RE-MEDY эффективность дабигатрана (150 мг 2 раза в день) в отношении предупреждения рецидивирующих и фатальных эпизодов ВТЭО не уступала таковой варфарина, а по влиянию на риск геморрагических осложнений дабигатран оказался более безопасным. В исследовании RE-SONATE по сравнению с плацебо дабигатран снижал риск рецидива ВТЭО на 92%, но увеличивал при этом риск больших или клинически значимых малых кровотечений в 2,9 раза.

Об авторах

Н. М. ВОРОБЬЕВА
Russian Cardiology Research and Production Complex FGBU of the Ministry of Health of the Russian Federation, Moscow
Россия
д.м.н.


Е. П. ПАНЧЕНКО
Russian Cardiology Research and Production Complex FGBU of the Ministry of Health of the Russian Federation, Moscow
Россия
д.м.н., профессор


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Для цитирования:


ВОРОБЬЕВА Н.М., ПАНЧЕНКО Е.П. ВОЗМОЖНОСТИ ДАБИГАТРАНА ЭТЕКСИЛАТА В ЛЕЧЕНИИ ВЕНОЗНЫХ ТРОМБОЭМБОЛИЧЕСКИХ ОСЛОЖНЕНИЙ. Атеротромбоз. 2015;(2):17-31. https://doi.org/10.21518/2307-1109-2015-2-17-31

For citation:


Vorobieva N.M., Panchenko E.P. DABIGATRAN ETEXILATE FOR THE TREATMENT OF VENOUS THROMBOEMBOLIC COMPLICATIONS. Atherothrombosis. 2015;(2):17-31. (In Russ.) https://doi.org/10.21518/2307-1109-2015-2-17-31

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ISSN 2307-1109 (Print)
ISSN 2658-5952 (Online)