HOW TO CREATE A LABORATORY EXAMINATION PROGRAM FOR A PATIENT WITH BLOOD-CLOTTING DISORDERS

Abstract

Impairments in haemostatic system function may result in the clinical manifestations in the form of haemorrhagic and/or thrombotic episodes and their combinations. Such cases are widespread in clinical practice, and a physician across specialties may face them. The creation of a laboratory examination program at the initial stage and in the follow-up of a patient depends on the clinical situation and working hypothesis, on the involvement of various mechanisms of the haemostasis system. Screening tests are the basis of the initial examination algorithms for the patient. Additional tests are added based on the initial examination results, clinical picture and medical history data. It is necessary to understand the essence of the performed examinations, their characteristics and the areas of responsibility of each in order to effectively use modern laboratory diagnostic capabilities. The most important clinical decisions can be made on the basis of the lab examination results — from establishing diagnosis to identifying the risks of recurrent thrombotic or haemorrhagic events and creating an appropriate secondary prevention program and choice of therapies, lifestyle changes, pregnancy planning and contraceptive methods.