FREQUENCY OF INHERITED THROMBOPHILIA GENE POLYMORPHISM IN WOMEN WITH REPRODUCTIVE HEALTH DISORDERS
https://doi.org/10.21518/2307-1109-2018-1-70-75
Abstract
This article analyzes the frequency of polymorphisms of hemostasis system and folate cycle protein genes associated with increased risk of thrombophilia based on the results of CHGMA (Chita State Medical Academy) genetic laboratory patients with reproductive health disorders. Method of research is allele-specific PCR. It was analyzed 1800 DNA samples. The most frequently mutations occur in the genes of receptors in the platelets and the folate cycle, mostly heterozygous substitution. Leiden mutation (F5) and prothrombin mutation (F2) are the most significant in the thrombophilia development and occur much less frequently. Only in one case revealed a homozygous mutation in the gene F2 and F5.
About the Author
A. V. Markovsky
FSBI HPE «Chita State Medical Academy» of the Ministry of Healthcare of the Russion Federation
Russian Federation
Chita
Russian Federation
Chita
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Review
For citations:
Markovsky A.V. FREQUENCY OF INHERITED THROMBOPHILIA GENE POLYMORPHISM IN WOMEN WITH REPRODUCTIVE HEALTH DISORDERS. Aterotromboz = Atherothrombosis. 2018;(1):70-75. (In Russ.) https://doi.org/10.21518/2307-1109-2018-1-70-75
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